LIFE XP – DNA SUPLEMMENT
What is Antioxidants and
Free Radicals?
Free radicals are everywhere, in the air, our bodies, and the materials around us. They cause the deterioration of plastics, the fading of paint, the degradation of works of art, aging related illnesses, and can contribute to heart attacks, stroke and cancers. Free radicals are molecules with unpaired electrons. In their quest to find another electron, they are very reactive and cause damage to surrounding molecules.
An apple slice turns brown. Fish becomes rancid. A cut on your skin is raw and inflamed. All of these result from a natural process called oxidation. It happens to all cells in nature, including the ones in your body. To help your body protect itself from the rigors of oxidation, Mother Nature provides thousands of different antioxidants in various amounts in fruits, vegetables, whole grains, nuts, and legumes. When your body needs to put up its best defense, especially true in today’s environment, antioxidants are crucial to your health
Telomere Damage Cell
DeathA 24-hour time lapse movie following light-induced oxidative telomere damage shows how daughter cells get stuck together by DNA fusion and ultimately die.
Credit: Fouquerel et al. (2019). Mol Cell.
The Danger of
Free Radicals.
When free radicals are on the attack, they don’t just kill cells to acquire their missing molecule. “If free radicals simply killed a cell, it wouldn’t be so bad… the body could just regenerate another one,” he says. “The problem is, free radicals often injure the cell, damaging the DNA, which creates the seed for disease.”
When a cell’s DNA changes, the cell becomes mutated. It grows abnormally and reproduces abnormally — and quickly.
What is Telomere?
Many people might have never heard of telomeres before, but telomeres are very important to our lives because they are one of the major determinants of ageing. Telomeres, the DNA that protects the ends of the chromosomes, helps maintain the structure of the DNA strands so that when the cells divide, the genetic code will be replicated properly. . To make it easier to understand, telomeres are like the plastic ends of our shoelaces. However, the length of each person’s telomeres is different due to genetics. But our telomeres shrink every time the cells divide themselves up as to repair the body. Besides, ageing also affects the telomeres, or the older you are, the shorter are the telomeres. At one point, the cells will enter the ‘degenerative’ stage in which the cells stop dividing which affect the overall health of our body. But what is even more interesting, how fast or slow the telomeres shrink.
When your lifestyle has become “toxic,” what happens to your telomeres?
We can see that the deterioration or ageing of the body can come sooner or later according to our “toxic” lifestyle. Both eating and sleeping patterns, as well as stress, can cause a chain reaction in the body, and by the time you realise it, the free radicals that have been accumulated in the body over the years have already attacked the healthy cells. This does not only weaken your telomeres, but it also weakens the body as well.
Aging is the multidimensional process of changes in physical, physiological and behavioral condition of a cell over time. It is characterized by decline of multiple physiological functions that increase the probability of homeostatic imbalance and cellular death. Various free radicals are produced due to endogenous oxidative reactions.
These highly reactive atoms cause oxidative damage and shorten lifespan of a cell. The antioxidants are the molecules, which neutralize free radicals and delay the cellular aging.
But what is even more important, our lifespan and lifestyle are linked to our telomeres !
Everyone is born with a healthy lifespan; and the telomeres are long in length. But as we age, the length of the telomeres become shorter and shorter until the cells stop dividing and cease functioning, which is one of the reasons why we become old, and our body is not as healthy as it used to be. Therefore, in a way, the key to our youth is hidden inside the DNA.
There might not be a perfect formula to live long and stay strong, but Life Xp this DNA supplement with Anthocyanol ( Maqui Berry antioxidants extract )can help you keeping your telomeres healthy every day.
free radical control
precursor NAD+
Epigenetic regulation
supporting skin tone
Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview. (2021)
the age-related diseases are associated with tissue dysfunction and macromolecular damage, can be attributed to accumulation of oxidative damage. Several studies collectively suggests that the intake of polyphenols and their major food sources may exert beneficial effects on improving insulin resistance and related diabetes risk factors, such as inflamamation and oxidative stress. Polyphenolic intake has been shown to be effective at ameliorating several age-related phenotypes, including oxidative stress.
Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis. (2019)
Telomeres are essential for genome stability. Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere shortening. Acute telomeric 8-oxoG formation increased telomere fragility in cells lacking OGG1, the enzyme that removes 8-oxoG. Accumulation of telomeric 8-oxoG in chronically exposed OGG1-deficient cells triggers replication stress, as evidenced by mitotic DNA synthesis at telomeres, and significantly increases telomere losses.
Aging, Oxidative Stress and Antioxidants. (2013)
Developing natural or pharmacological agents capable of increasing the antioxidative protection and/or modulating the endogenous defense and repair mechanisms may potentially improve health, increase longevity and contribute to treatment
of degenerative age-related diseases. Synthetic antioxidant supplements may help to correct the high levels of oxidative stress that cannot be controlled by the sinergy of endogenous antioxidant systems.
Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases. (2018)
Of particular interest in this article, we highlighted the molecular mechanisms of antioxidants involved in the prevention of age-related diseases. Taken together, a better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.
Telomere shortening rate predicts species life span. (2019)
Telomere shortening to a critical length can trigger aging and shorter life spans in mice and humans by a mechanism that involves induction of a persistent DNA damage response at chromosome ends and loss of cellular viability.
These results support the notion that critical telomere shortening and the consequent onset of telomeric DNA damage and cellular senescence are a general determinant of species life span.
Effects of antioxidant supplementation on the aging process, (2007)
The identification of free radical reactions as promoters of the aging process implies that interventions aimed at limiting or inhibiting them should be able to reduce the rate of formation of aging changes with a consequent reduction of the aging rate and disease pathogenesis. Even if antioxidant supplementation is receiving growing attention and is increasingly adopted in Western countries.